science

So they fed LSD and humans to dogs?

For my fellow clickbait haters

In a new paper published today in the journal Advanced Science, researchers from China and the U.K. become the first to demonstrate inter-brain activity coupling between two species. The study goes on to illustrate not only how a mutation associated with ASD is linked to much lower coupling, but how a dose of LSD could help two brains intertwine.

I’ve only read the headline but I bet it fucking did

In fact I’d love to trip with a dog

Based on the image, they definitely boned.

I took acid around my cat once. I think he could tell something was wrong and kind of tried to bring me round.

Once LSD becomes approved medication for ASD, my doctor will hear about my condition very fast

Using 10 beagles, the team performed 5 days of social experiments on pairs of unfamiliar dogs and humans. Participants wore electroencephalogram (EEG) caps to measure brain activity during 3 social interactions: when the human and dog were in different rooms, in the same room but not interacting, and in the same room while interacting, each for 5 minutes at a time. Inter-brain synchronization, the authors found, increased in the frontal and parietal lobes of the brain, both of which deal with attention, during the most intense social interactions like petting and looking at each other. This correlation continued to strengthen over the 5 days.

This is the baseline for comparison in the paper.

Next, the authors repeated the experiment using 13 dogs bred with Shank3 mutations, which are the most common genetic risk factors for ASD (autism spectrum disorder). The Shank3 mutants showed a loss of inter-brain activity coupling during interactions with humans, indicating this connection’s absence. However, 24 hours after administering a dose of LSD (7.5 μg per kg^-1 bodyweight), the authors observed much higher inter-brain correlation in the dogs’ frontal and parietal brain regions, outperforming dogs who had received a saline solution.

kg ^ -1 = 100 grams. So you can read it as 7.5 μg of LSD per 100 grams of dog. As to why that dose, from the paper:

we conducted a pilot study to determine an appropriate LSD dose at 7.5 µg kg−1 bodyweight, as 10 µg kg−1 bodyweight (inferred from previous reports on mice[13]) showed an apparent head-shaking effect, while 5 µg LSD kg−1 bodyweight showed no recognizable effect on the behaviors.

Full paper - https://onlinelibrary.wiley.com/doi/10.1002/advs.202402493

Dog telepathy?

40 up votes 20 down. interesting. sort of a community inflection point. magical