Yes! BTRFS is awesome and there is BTRBK to do backups.
You can do a lot, backup only some subvolumes and way more, it supports deduplication and copy on write, which is worlds apart regular updating systems
A good GUI for that is really needed. Currently just using rsync as its pretty easy with some arguments
rsync --av --compress --partial --progress --update --sparse --delete --exclude "folder1" --exclude "folder2" /FROM/DIR /TO/DIR