I use NixOS on my main PC.
If you want to use NixOS, you have to be willing to read.
Two things are especially difficult:
Coding: You will have to learn the Nix-specific way for everything you do. How does Nodejs work in NixOS? How does GCC work in NixOS? How does my IDE work in NixOS?
Using unofficial packages: The nix repos are very large and you'll most likely find everything you need there (or on flatpak/flathub). But if something isn't there, the easiest way tends to be packaging it as a nix package yourself. And that's something many people probably don't want to do.
The coding thing is annoying enough that I may switch away from NixOS at some point.
Other than that, NixOS is great.