No, my kids are certainly diverse in sexual preference and one is transgender, but I didn't have any sort of unacceptance. I grew up around drag queens and "theater people".
Maybe in the other direction, honestly - I didn't see the trans one until they literally came out by telling me, my conception of womanhood is so broad that my kid looking like a 40 year old butch lesbian did not ping any trans radar so I was surprised when they said they wanted to be a man. Not mad or anything but it took awhile to process.
Nobody else has had to "come out" or worry about the race or sex of who they are with, they can bring home whoever they are going out with and we don't blink, it's fine.