I’m AFAB enby, saying “you guys” and calling me “dude” is fine. Those to me aren’t gendered anymore. The people who get offended at general terms like these for groups of people need to touch grass.
But if you’re dead set on it, embrace y’all lol. Just don’t say it with a southern drawl and you’ll be fine. It’s a fantastic gender neutral term. You can also just train yourself not to add in the “you guys” to the “what’s up” phrase, and maybe just say “what’s up with you?” “What’s up with you all?” Etc.
It’s good that OP means well, but also there are so many of us who do not care and are not affected because we know the speaker is using a generalized term and isn’t (usually) being malicious with it. I call several of my cisgender girl friends “dude” and “bro” and I’ll call men “girl” as a joke sometimes (like, girl what are you doing?). Many of these terms simply have completely lost their original gendered meaning in a lot of contexts.