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The Rolling Stones fly to Los Angeles to record "Get Off My Cloud". In a later interview, Keith Richards would say "I never dug it as a record. The chorus was a nice idea, but we rushed it as the follow-up" (to "Satisfaction").

John Lennon and Yoko Ono appear on Jerry Lewis' Muscular Dystrophy Telethon. Lewis introduced the pair by saying, "... two of the most unusual people in all the world, and I don't mean just in the world of entertainment. They fit no patterns, meet no standards except the standard of excellence. Ladies and gentlemen, John Lennon and Yoko." From the Hotel Americana in New York City, John and the Elephant's Memory band performed "Imagine", followed by Yoko singing her new song "Now or Never". The ensemble wrapped things up with a Reggae version of "Give Peace a Chance", on which Jerry Lewis joined in on trumpet.

The Beatles release "Yesterday", on which only Paul is actually playing. Although it was nominated for Song of the Year at the 1966 Grammy Awards, it lost out to Tony Bennett's "The Shadow of Your Smile". More than 2,500 cover versions of "Yesterday" exist, making it one of the most recorded songs in history. In 2012, the BBC reported that it was the fourth-most-successful song of all time in terms of royalties paid, having earned a total of £19.5 million in payments.

The Rock group Blondie, featuring former Playboy Bunny Debra Harry, sign their first major record company contract with Chrysalis Records.

The Rolling Stones release the LP "Goats Head Soup" on their own Rolling Stones label. The album, which climbed to the peak of the charts in both America and England, features the single, "Angie" which topped the Billboard Hot 100 and went to #5 on the UK's Official Chart

The three-day Texas International Pop Festival opens at the Dallas International Motor Speedway. Performers included Chicago Transit Authority, Janis Joplin, Led Zeppelin and Santana.

Monument Records releases Rob Orbison's "Oh, Pretty Woman". It will hit Billboard's number one spot just four weeks later and reach the Top Ten in fifteen other countries. The RIAA would later award songwriters Roy Orbison and Bill Dees a Gold Record for selling one million copies in the United States.

The Beatles smoke marijuana for the first time, supplied by Bob Dylan, who joins the band after one of their concerts in New York state. Dylan was surprised the boys hadn't tried it before, as he thought they sang "I get high" in their song "I Want To Hold Your Hand," when the real lyrics were actually "I can't hide."

The Beatles' manager Brian Epstein was found dead of an apparent drug overdose at his home in Belgravia, London, just a few weeks shy of his 33rd birthday. The Fab Four were in Bangor, North Wales at the time, attending a conference by the Maharishi Mahesh Yogi. The death is ruled accidental and the Maharishi tells the Beatles that Epstein's death, being in the realm of the physical world, is "not important." The group would later renounce their association with the Maharishi and Epstein is remembered as being the man who took The Beatles from being a rough looking club act to the most successful band in the world. John Lennon would later recall that when he heard the news about Brian, "I thought, we've fuckin' had it."

A crowd of 80,000 people attended the first Canada Jam Festival held at Mosport Park, just north of Bowmanville, Ontario. The show featured sets by The Doobie Brothers, Dave Mason, The Commodores, Kansas and The Atlanta Rhythm Section.

Led Zeppelin's Jimmy Page and Robert Plant reunited at LWT studios in London to tape a set for MTV's Unplugged series, set to air on October 12th. Bassist John Paul Jones was not included.

While celebrating his 21st Birthday, The Who's drummer, Keith Moon drives a Lincoln Continental into the pool of a Holiday Inn in Flint, Michigan. The band would later get a $50,000 bill for the damage they caused and were subsequently banned from every Holiday Inn for life. It was also rumored that Decca Records had to purchase the ruined car from its rightful owner.