I think in this context no ship would ever approach nose-to-nose. That's just for the viewers to see. I'd wager no two ships would come into less than around 1-5 km of each other if they weren't lining up flight paths for shuttles or docking. It's not like they need to "stand up" next to each other and "talk".
They would probably have formations they would assume while in transit or stopped, so it would probably be normal to cross paths with a formation flying upside down or in a perpendicular axis.
In case of just meeting and talking, they'd probably do it from wherever they happen to be, very far from each other, flying towards different destinations. In case of combat, they would behave like a swarm of insects and reorient their formations continuously.