Linux 101 stuff. Questions are encouraged, noobs are welcome!

Hi,

I'm considering transitioning completely to Linux for my main workstation. However, due to the nature of my work I rely extensively on a few Autodesk products (namely AutoCAD, Revit) as well as Ms OneDrive to coordinate with clients. I did some research and these applications are not available natively and can't run through Wine. So I was thinking setting up a virtual machine with a windows image in order to run these two programs. They don't need extensive GPU. I was wondering if there are any obstacles / issues I should be aware if I chose to go this route? Thanks!