I won't pretend to have such deep knowledge as to claim to know they're safe, but as far as I'm aware (which again, is some, but am not a medical professional), the N of the SNRI shouldn't really be affected directly. But that doesn't mean that if you get a little bit jittery when you're going up that you won't have increased norepinephrine which would then be blocked from reuptake.

So yeah, it's somewhat more complicated. Anticonvulsants are basically what you'd use to come down from a trip (depending on which type, there's a lot), so I don't see any obvious risks in that either. GABA should likewise not be a problem, as not directly affected, and like anticonvulsants, some of them are used as anti-psychotics.

However with those meds, even if I could say it's safe (whichever again, I can't, but personally believe it to be of low risk, due to the things I've read concerning), I don't know if I'd say it's worth it, really.

Like you wouldn't enjoy a night out if you had the flu, basically, but it wouldn't be that risky. Even though like getting a bad case of pneumonia and not treating it might be fatal, but quite a small risk. Probably on the same level, these risks.

collectively, who knows?

No-one, honestly. But the internet is pretty hard at work on it.

Although they started with recreational polysubstance combinations, actual meds don't appear on the list too often unless they can be uses recreationally.

https://en.m.wikipedia.org/wiki/List_of_polysubstance_combinations

But yeah, safety is #1 when using drugs.