this post was submitted on 16 Sep 2024
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[–] swlabr@awful.systems 40 points 2 months ago (14 children)

I hate hate hate this so much. This is precisely the kind of smug, reductionist, dunning-kruger, every-problem-is-a-nail-and-programming-is-my-hammer type of shit that fuels my hatred of not only TESCREAL but pretty much everyone I meet in STEM.

[–] Soyweiser@awful.systems 17 points 2 months ago* (last edited 2 months ago) (13 children)

I wonder how much of the coder mindset is behind the anarchist diy chemistry biohacking people (which seems to distress people who have actual experience in chemistry).

[–] skillissuer@discuss.tchncs.de 11 points 2 months ago* (last edited 2 months ago) (10 children)

these people are full of shit. sofosbuvir contains single fluorine atom in such a place that its introduction requires either hydrogen fluoride (also as NEt3.3HF) or DAST (or other very friendly reagents like Xtalfluor-E) and even then, synthesis sucks balls as in has low-to-medium yield (15-50%) and requires extensive purification. you do not, under any circumstances, fuck around with hydrogen fluoride in your garage

relevant patent https://worldwide.espacenet.com/patent/search/family/051842422/publication/WO2016066283A1?q=pn%3DWO2016066283 first few pages for literature review, around 97-102 for procedures. these sub-50% yields are already heavily optimized

[–] Soyweiser@awful.systems 7 points 2 months ago (1 children)

hydrogen fluoride

Yes one of the !!fun!! chemicals.

[–] chunkystyles@sopuli.xyz 5 points 2 months ago (1 children)
[–] Soyweiser@awful.systems 4 points 2 months ago

Here have a welcoming gift. *hands over !!«☼Rope Reed Left Sock☼»!!

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