Noise cancelling and audiophile can be tough. Noise blocking... maybe Etymotic ER2XR. Easy to drive, block noise, very audiophile. I have owned a lot of headphones but these days I mostly use Airpod Pro 2. The NC is great, they are small, and sound ok. I like that the NC is easy to toggle on and off. The Etymotic headphones sound great and block lots of noise but they are hard to constantly be putting in and taking out. The cable can get annoying too.
I am waiting for Ety to make something more modern.
Now do how they split!