this post was submitted on 25 Oct 2024
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2024-11-11

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Feeding a baby born by caesarean section milk containing a tiny bit of their mother’s poo introduces beneficial microbes to their gut, according to a clinical trial. The approach might one day help to prevent diseases during childhood and later in life.

Some studies show that babies born by c-section, rather than vaginal birth, have a higher risk of asthma, inflammation of the digestive system and other diseases associated with a dysfunctional immune system... Experiments have attempted to compensate for that by swabbing babies born by c-section with microbes from their mother’s vagina or giving them these microbes orally, a practice known as ‘vaginal seeding’. But this technique has had limited success, because vaginal microbes, scientists have learnt, cannot effectively colonize infants’ guts...

Helve and his colleagues have been pioneers in testing whether faecal transplants can instead improve the health of a baby’s microbiome. In their latest trial, which recruited women scheduled for a c-section at the Helsinki University Hospital, the researchers mixed a fluid containing 3.5 milligrams of a mother’s poo into milk and gave the concoction to the corresponding baby. They did this for 15 babies during their first feed. Another 16 babies received a placebo.

An important next step in the field, Shao says, would be to pinpoint the specific maternal gut microbes that are most likely to transmit to and colonize their babies’ guts. Shao asks: “If these species do exist across human populations, wouldn’t it be more effective and safer” to give newborns a laboratory-made transplant that’s guaranteed to be pathogen-free?

"This is the shit"

But seriously don't try this at home. Fecal matters can contain pathogens, in fact 54 of the 90 women screened were excluded because of detected pathogens. If this goes well maybe ppl can make some type of lab-made probiotics for C-section babies or stuff

The abstract presented at IDWeek 2024: https://idweek2024.eventscribe.net/index.asp?presTarget=2886841

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[–] SpaceNoodle@lemmy.world 32 points 4 weeks ago (3 children)

As someone who was extracted via C-section and has lifelong chronic respiratory and digestive issues, I find this fascinating.

Gonna hit my moms up for some dookie when we chat on Sunday

[–] Crackhappy@lemmy.world 13 points 4 weeks ago

Hey Mom, gimme some of that good shit.

[–] Notyou@sopuli.xyz 4 points 4 weeks ago (1 children)

Just so you know, they found out that any healthy dookie helps and not just from your mom.

[–] SpaceNoodle@lemmy.world 10 points 4 weeks ago* (last edited 4 weeks ago) (1 children)

Oh thank god. Now I don't have to talk to her

I don't think I know any healthy people though

[–] Notyou@sopuli.xyz 2 points 4 weeks ago (1 children)

I would volunteer if it meant you didn't have to talk to your mother again.

[–] SpaceNoodle@lemmy.world 5 points 4 weeks ago

Stop trying to get me to eat your poop

[–] GBU_28@lemm.ee 2 points 4 weeks ago
[–] cccrontab@lemmy.world 9 points 4 weeks ago

I never want to see those 2 words used together ever again.

[–] Thcdenton@lemmy.world 8 points 4 weeks ago (2 children)

You had me at poo milkshake

[–] phantomc137@lemmy.world 2 points 4 weeks ago

homelander 🤤

[–] TastyWheat@lemmy.world 1 points 4 weeks ago

Triumph! Haven't seen that dog in ages!

[–] Odo@lemmy.world 8 points 4 weeks ago

Poo milkshake

"Poothie" was right there.

[–] haerrii 6 points 4 weeks ago

Babe what's up? You barely touched your postnatal poo milkshake.

[–] veganpizza69@lemmy.vg 6 points 4 weeks ago

Different study:

Early-life microbiota seeding and subsequent development is crucial to future health. Cesarean-section (CS) birth, as opposed to vaginal delivery, affects early mother-to-infant transmission of microbes. Here, we assess mother-to-infant microbiota seeding and early-life microbiota development across six maternal and four infant niches over the first 30 days of life in 120 mother-infant pairs. Across all infants, we estimate that on average 58.5% of the infant microbiota composition can be attributed to any of the maternal source communities. All maternal source communities seed multiple infant niches. We identify shared and niche-specific host/environmental factors shaping the infant microbiota. In CS-born infants, we report reduced seeding of infant fecal microbiota by maternal fecal microbes, whereas colonization with breastmilk microbiota is increased when compared with vaginally born infants. Therefore, our data suggest auxiliary routes of mother-to-infant microbial seeding, which may compensate for one another, ensuring that essential microbes/microbial functions are transferred irrespective of disrupted transmission routes. https://www.cell.com/cell-host-microbe/fulltext/S1931-3128(23)00043-4

[–] Kolanaki@yiffit.net 1 points 4 weeks ago
[–] Sundial@lemm.ee -2 points 4 weeks ago (1 children)

Why is this study for only babies born by caesarean section and not all babies?

[–] zlatiah@lemmy.world 16 points 4 weeks ago (1 children)

This is the study they were referring to: https://doi.org/10.1016/j.jaci.2015.07.040

C-section babies have slightly higher risks of several diseases related to immune system function, and the hypothesis is that it is because these babies have slightly less developed immune systems

[–] Sundial@lemm.ee 3 points 4 weeks ago (1 children)

I took a quick look at the study and it didn't mention anything about digestion or fecal matter being used? How does that relate to helping a babies immune system?

[–] zlatiah@lemmy.world 8 points 4 weeks ago (1 children)

I clearly didn't drink enough coffee for this before posting

My bad, the original news article did a good job at explaining the missing link... I misunderstood what you were asking

  • C-section babies seem to have more immune system-related diseases (https://doi.org/10.1016/j.jaci.2015.07.040), so scientists think they would benefit from special treatment
  • Scientists tried to fix this by giving the babies vagina-derived bacteria (https://doi.org/10.1038/nm.4039); couldn't find any more reports on this but it seems like these don't work super well?
  • This is a proof-of-concept by the lab highlighted in the news (https://doi.org/10.1016/j.cell.2020.08.047), they tried using fecal matter and it worked
  • The abstract featured in the news is now a clinical trial that is in progress

I think that's pretty much it

[–] Sundial@lemm.ee 4 points 4 weeks ago (1 children)

The summary from the last link connected the dots for me.

Thanks for the insights. Enjoy your coffee :).

[–] TastyWheat@lemmy.world 2 points 4 weeks ago

I hope OP didn't skimp on the milk :)