this post was submitted on 16 Sep 2024
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these people are full of shit. sofosbuvir contains single fluorine atom in such a place that its introduction requires either hydrogen fluoride (also as NEt3.3HF) or DAST (or other very friendly reagents like Xtalfluor-E) and even then, synthesis sucks balls as in has low-to-medium yield (15-50%) and requires extensive purification. you do not, under any circumstances, fuck around with hydrogen fluoride in your garage
relevant patent https://worldwide.espacenet.com/patent/search/family/051842422/publication/WO2016066283A1?q=pn%3DWO2016066283 first few pages for literature review, around 97-102 for procedures. these sub-50% yields are already heavily optimized
Yes one of the !!fun!! chemicals.
Hello, Urist.
Here have a welcoming gift. *hands over !!«☼Rope Reed Left Sock☼»!!